Palladium's Nightbane (1995)
Zack: Hell yes, now we're into the real stuff. The horrors of drug addiction, which, like everything, can be accurately modeled with a random table.
Steve: So wait a second, any drug can have any effect?
Zack: Yup! The game that has detailed stats for 25 different pistols reduces drugs to a video game pill that you take and suffer a random consequence.
Steve: Some of these aren't even bad.
Zack: Smoked a joint and hallucinated my wife was a unicorn angel wearing nothing but belts and I could not parry him!
Steve: Don't worry, dude, he was more afraid of you than you were of him.
